Histology
Clone E6H4
Kong CS et al. p16INK4A Immunohistochemistry is Superior to HPV In Situ Hybridization for the Detection of High-risk HPV in Atypical Squamous Metaplasia. Am J Surg Pathol 2007;31:33-43Nucci MR, Crum CP. Redefining Early Cervical Neoplasia: Recent Progress. Adv Anat Pathol 2007;14:1-10
Regauer S, Reich O CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III). Histopathology 2007; 50: 629?635
Christal JL et al. The Utility of p16 Immunohistochemistry in the Diagnosis of Cervical Intraepithelial Neoplasia. Pathology Case Reviews 2006; 11: 117-120
Ishikawa M et al. Overexpression of p16INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia. Int J Gynecol Cancer 2006; 16: 347-353
Kang SJ, et al. Methylation of p16INK4a Is a Non-Rare Event in Cervical Intraepithelial Neoplasia. Diagn Mol Pathol 2006;15:74-82
Liang J, et al. Utility of p16INK4a, CEA, Ki67, P53 and ER/PR in the Differential Diagnosis of Benign, Premalignant, and Malignant Glandular Lesions of the Uterine Cervix and Their Relationship with Silverberg Scoring System for Endocervical Glandular Lesions. Int J Gyn Pathol 2006; 26:71-75
Queiroz C et al. p16INK4a Expression as a Potential Prognostic Marker in Cervical Pre-Neoplastic and Neoplastic Lesions. Pathology - Research and Practice 2006; 202: 77-83
Kalof AN et al. p16INK4a Immunoexpression and HPV In Situ Hybridization Signal Patterns Potential Markers of High-Grade Cervical Intraepithelial Neoplasia.
Am J Surg Pathol 2005; 29: 674-679
Lorenzato M. Cell cycle and/or proliferation markers: what is the best method to discriminate cervical high-grade lesions?. Human Pathology 2005; 36: 1101-1107
Missaoui N et al. p16INK4a Overexpression and HPV Infection in Uterine Cervix Adenocarcinoma. Virchows Arch 2005
Parwani AV et al. Cervical Adenoid Basal Tumors Comprised of Adenoid Basal Epithelioma Associated with Various Types of Invasive Carcinoma: Clinicopathologic Features, Human Papillomavirus DNA Detection, and P16 Expression. Human Pathology 2005; 36: 82-90
Ansari-Lari MA et al. Distinction of Endocervical and Endometrial Adenocarcinomas Immunohistochemical p16 Expression Correlated With HumanPapillomavirus (HPV) DNA Detection. Am J Surg Pathol 2004; 28: 160-167
McCluggage WG. Re: Distinction of Endocervical and Endometrial Adenocarcinomas Immunohistochemical p16 Expression Correlated With Human Papilloma Virus (HPV) DNA Detection. Am J Surg Pathol 2004; 28: 974-975
Negri G et al. p16INK4a Expression and Progression Risk of Low-Grade Intraepithelial Neoplasia of the Cervix Uteri. Virchows Arch 2004; 445: 616-620
Schorge JO et al. P16 as a Molecular Biomarker of Cervical Adenocarcinoma. American Journal of Obstetrics and Gynecology 2004; 190: 668-73
Volgareva G et al. Protein p16 as a Marker of Dysplastic and Neoplastic Alterations in Cervical Epithelial Cells. BMC Cancer 2004; 4: 58
Wang SS et al. Validation of p16INK4a as a Marker of Oncogenic Human Papillomavirus Infection in Cervical Biopsies from a Population-Based Cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev 2004 ; 13: 1355-60
Agoff SN et al. p16INK4a Expression Correlates with Degree of Cervical Neoplasia: A Comparison with Ki-67 Expression and Detection of High-Risk HPV Types. Mod Pathol 2003; 16: 665-673
Ishikawa M et al. Correlation of p16INK4a Overexpression with Human Papillomavirus Infection in Cervical Adenocarcinomas. International Journal of Gynecological Pathology 2003; 22: 378-385
McCluggage WG et al. P16 Immunoreactivity May Assist in the Distinction Between Endometrial and Endocervial Adenocarcinoma. International Journal of Gynecological Pathology 2003; 22: 231-235
Masumoto N. p16INK4a Overexpression and Human Papillomavirus Infection in Small Cell Carcinoma of the Uterine Cervix. Human Pathology 2003; 34: 778-783
Negri G et al. p16INK4a is a Useful Marker for the Diagnosis of Adenocarcinoma of the Cervix Uteri and Its Precursors. An Immunohistochemical Study With Immunocytochemical Correlations, The American Journal of Surgical Pathology. Lippincott Williams & Wilkins, Inc., Philadelphia 2003; 27(2): 187-193.
Zielinski GD et al. The Presence of High-Rsk HPV Combined with Specific p53 and p16INK4a Expression Patterns Points to High-Risk HPV as the Main Causative Agent for Adenocarcinoma In Situ and Adenocarcinoma of the Cervix. J Pathol 2003; 201: 535-543
Klaes R et al. p16INK4a Immunohistochemistry Improves Interobserver Agreement in the Diagnosis of Cervical Intraepithelial Neoplasia. The American Journal of Surgical Pathology 2002; 26: 1389-1399
Klaes R et al. Overexpression of p16INK4a as a Specific Marker for Dysplastic and Neoplastic Epithelial Cells of the Cervix Uteri. Int J Cancer. 2001; 92: 276-284
